There are three stages of mono (mononucleosis):
- Prodrome stage, when symptoms start
- Acute stage, when you feel the worst
- Convalescent stage, when you begin to recover
These begin after a period of incubation, in which mono is in your system, but there are no obvious signs of it yet.
Some people may have symptoms for only two to six weeks. Others may have lingering effects—especially fatigue—until the virus that causes the illness becomes inactive, which can take months.
This article walks you through the stages of mono so you can get a better sense of what to expect and how to get over mono faster. It also looks at possible complications and ways to prevent getting mono and passing the virus to others.
How Long Does Mono Fatigue Last?
Mono Incubation Period
The Epstein-Barr virus (EBV) is the most common cause of mono. It can take around four to six weeks for symptoms of mononucleosis to appear after you have been infected.
The period of time between exposure and the start of symptoms is called the incubation period.
Though may feel OK during this time, it's still possible for you to pass the virus on to others.
Mono Stage 1: Prodrome
The first stage of mono is called the prodrome stage. It ususally lasts three to five days.
Mono symptoms start to appear during this phase. These can include:
- Fatigue or low energy
- Feeling "off" or uncomfortable
- Not feeling hungry
- Sore throat
You can also have mono without symptoms. In particular, kids under the age of 10 may have very mild symptoms or none at all.
How Can You Tell If You Have Mono?
Mono Stage 2: Acute Phase
The second phase of mono is called the acute stage. During this time, a person's symptoms may start to get worse. Acute symptoms are often referred to as "classic" symptoms.
By and large, the acute symptoms of mono last for two to six weeks but may persist longer in some people.
Not everyone will experience every symptom of mono. Keep in mind that mono symptoms can also show up at different times over the course of the infection.
How Mono Is Diagnosed
Mono Stage 3: Convalescent Phase
The last phase of mono is the convalescent stage. This is when you recover from the infection, which can take anywhere from three to six months.
By this stage, most mono symptoms have gotten better. However, some people still feel weak and tired.
If you have an inflamed or enlarged spleen during the convalescent stage, you will need to avoid any physical activity that could lead to spleen rupture.
How Long Is Mono Contagious?
Even after symptoms have cleared, the virus can be passed in saliva for up to 18 months.
Can You Get Mono More Than Once?
Mono Treatment
There's no cure or specific treatment for mono. It can take a long time to get over the infection, and there's not much you can do to make the process go faster.
Supporting your body as it heals and fights off the virus is the best approach.
You can do this by:
- Resting and getting plenty of fluids
- Using over-the-counter (OTC) or prescription medications for pain and fever (Ask your provider before you use acetaminophen, as this medication can increase the risk of liver damage.)
- Taking medications for inflammation, if needed
Providers may prescribe a corticosteroid if you have a severe case of mono.
What Are the Symptoms of Mono in Kids?
Do I Need to Isolate If I Have Mono?
Mono can be passed to others, but you don't necessarily need to isolate when you are infected—if you follow certain precautions.
The mono virus is mostly spread through your spit (saliva). Mono can also spread if you cough or sneeze close to somebody.
When you are around others:
- Avoid sharing eating and drinking utensils.
- Refrain from kissing.
- Do not share personal items, like lip balms.
- Cover your coughs and sneezes using the inside of your elbow.
- Wash your hands frequently.
How to Prevent the Transmission of Mononucleosis
Complications of Mono
People with severe mono can experience liver and spleen damage. There are also some other potentially serious complications of mono, such as:
- Jaundice (when a substance called bilirubin builds up and causes the skin and whites of the eyes to look yellow)
- Liver failure
- Peritonsillar abscess (an infection in the throat)
- Encephalitis (inflammation in the brain)
- Pleural effusion (fluid build-up in the lungs)
The effects of these complications may persist even after you've recovered from mono itself.
Studies have shown that the Epstein-Barr virus might be linked to certain types of cancer, including Burkitt’s lymphoma and Hodgkin lymphoma.
Mono has also been associated with an increased risk of developing autoimmune diseases like multiple sclerosis.
Rarely, people with mono can develop a chronic active Epstein-Barr virus (CAEBV) infection. This can occur in people with a first-time infection or in people who have already recovered from the illness if the virus reactivates within the body.
Does Mono Cause Cancer?
When to See a Healthcare Provider
Your symptoms should start to improve in a week or two. If they don't, make another appointment with your healthcare provider.
You should also contact your healthcare provider if:
- You have an extreme headache or severe body aches
- You have weakness in your arms or legs
- You have a persistent high fever
- You feel dizzy or faint
When to Go to the ER
Some complications of mono can be life-threatening. Seek emergency care at once if you develop:
- Sudden, sharp pain in your upper left abdomen
- Trouble breathing or swallowing
- A stiff neck
- Extreme fatigue/weakness
Summary
Mono is a contagious illness that is usually caused by the Epstein-Barr virus. Mono has three stages: prodrome (when symptoms start), acute stage (when symptoms worsen), and convalescent (recovery).
Mono has a long incubation period, so it can be difficult to pinpoint when the illness actually started. On average, the prodrome phase lasts three to five days, the acute phase can last up to six weeks, and the final recovery stage can go on for up to six months.
Is Mono an STD?
Frequently Asked Questions
Does mono ever go away completely?
Once you get mono, the virus will always stay in your body. However, it will not always be active. That means you won't always be sick and you won't always be able to spread the virus to other people.
Learn More:Can You Have Chronic Mono?
What causes mono?
Mono is most often caused by the Epstein-Barr virus, but about 10% of cases are due to other viruses. While having the virus that causes mono is very common, only a small number of people actually get mono.
(Video) Can You Treat Mono, and How Long Does It Last? | Tita TVLearn More:Who's at Higher Risk for Mono?
Home Remedies for Mono
10 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
Becker JA, Smith JA. Return to play after infectious mononucleosis. Sports Health. 2014;6(3):232-238. doi:10.1177/1941738114521984
Stock I. Infectious mononucleosis--a “childhood disease” of great medical concern. Med Monatsschr Pharm. 2013;36(10):364-368.
Saljoughian M. Diagnosing and treating mononucleosis. US Pharm. 2017;42(5):HS-7-HS-10.
Balfour HH, Dunmire SK, Hogquist KA. Infectious mononucleosis.Clin Trans Immunol. 2015;4(2):e33. doi:10.1038/cti.2015.1
Johns Hopkins Medicine. Infectious mononucleosis.
Zhang L, Zhou P, Meng Z, et al. Infectious mononucleosis and hepatic function. Exp Ther Med. 2018;15(3):2901-2909. doi:10.3892/etm.2018.5736
Herold J, Grimaldo F. Epstein-Barr virus-induced jaundice. Clin Pract Cases Emerg Med. 2020;4(1):69-71. doi:10.5811/cpcem.2019.10.45049
Kimura H, Cohen JI. Chronic active Epstein-Barr virus disease. Front Immunol. 2017;8:1867. doi:10.3389/fimmu.2017.01867
Nemours. How long Is mono contagious?.
(Video) A ANSWER AT LAST! | Mono Recovery UpdateDunmire SK, Hogquist KA, Balfour HH. Infectious Mononucleosis.Curr Top Microbiol Immunol. 2015;390(Pt 1):211-240. doi:10.1007/978-3-319-22822-8_9
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FAQs
How Long Does Mono Last? ›
Most people get better in two to four weeks; however, some people may feel fatigued for several more weeks. Occasionally, the symptoms of infectious mononucleosis can last for six months or longer.
How long is mono contagious for? ›The average length of time a person is contagious after onset of illness is six months. The EB virus remains in the body for life, and periodically can be found in small amounts in the throat in otherwise completely healthy persons. For this reason, it is good to limit the casual sharing of body fluids at all times.
How long does it take to recover from mono? ›Most signs and symptoms of mononucleosis ease within a few weeks, but it may be two to three months before you feel completely normal. The more rest you get, the sooner you should recover. Returning to your usual schedule too soon can increase the risk of a relapse.
What are the four stages of mono? ›Are there stages of mono? Yes, there are three main stages for mono. The first one is the prodrome stage, followed by the acute stage, and the convalescent or recovery stage is the third and last stage of mono.
What happens if mono is left untreated? ›Mono Can Also Cause These Rarer Complications
Myocarditis This is an inflammation of the heart muscle. Nervous System Problems These include meningitis, encephalitis, Guillain-Barré syndrome, Bell's palsy, and seizures. Certain Cancers These include Burkitt lymphoma, Hodgkin lymphoma, and nasopharyngeal carcinoma.
Mono symptoms eventually go away, but in some cases it can be contagious for up to 6 months or more. The virus that commonly causes it — Epstein-Barr virus — remains in the body forever without causing symptoms. For most people, mono eventually resolves without any issues.
Is mono considered an STD? ›Technically, yes, mono can be considered a sexually transmitted infection (STI). But that's not to say that all cases of mono are STIs. Mono, or infectious mononucleosis as you might hear your doctor call it, is a contagious disease caused by Epstein-Barr virus (EBV).
When can I kiss after mono? ›As a precaution, you should avoid sharing drinking glasses, eating utensils, food, and kissing until your sore throat and other symptoms have disappeared for several (4-6) weeks.
When can I kiss my boyfriend after mono? ›This is a difficult question to answer. It is advisable to at least refrain from kissing while there are active symptoms present (i.e. sore throat, fever, swollen glands). Mono may be contracted from carriers (someone who has the organism causing the disease, but who does not become ill).
Can I go to work with mono? ›Many people with mono develop an enlarged spleen, which can last for a few weeks or longer. Although you can return to school or work when you are feeling better, it's important to avoid activities that can cause injury to the spleen.
What are the three stages of mono? ›
- The prodrome stage. Mono infection occurs in three stages. ...
- The acute phase. The acute phase, which can last for 2 to 6 days, is when the symptoms begin to worsen. ...
- The convalescent stage. The last stage is the convalescent or recovery stage, which can last from 2 to 6 months.
While the most common way for the virus to spread is, indeed, through saliva, you don't have to kiss someone with an active strain of it in order to contract it. It can also be transmitted by activities like sharing drinks and using another person's utensils, or through blood and other bodily fluids.
Do you always test positive for mono after having it? ›A small number of people with mononucleosis may never have a positive test. The highest number of antibodies occurs 2 to 5 weeks after mono begins. They may be present for up to 1 year. In rare cases, the test is positive even though you do not have mono.
What is the biggest symptom of mono? ›- extreme fatigue.
- fever.
- sore throat.
- head and body aches.
- swollen lymph nodes in the neck and armpits.
- swollen liver or spleen or both.
- rash.
Students with mono might need to: be absent from school for several weeks. have homework and assignments sent home and tests rescheduled. avoid gym class and sports until they get clearance from a doctor (the virus can cause the spleen to enlarge, creating a risk of rupture )
What is the fastest way to get rid of mono? ›- Rest: Mono makes you very tired. ...
- Hydration: Drink plenty of fluids to prevent dehydration.
- Pain relievers: Nonsteroidal anti-inflammatory drugs (NSAIDs) ease fever, inflammation, headaches and muscle aches. ...
- Sore throat soothers: You can gargle with salt water and use throat lozenges.
Most people have mono only once. In rare cases, the symptoms can recur due to a reactivation of EBV. If mono returns, the virus is in your saliva, but you probably won't have any symptoms unless you have a weakened immune system. In rare instances, mono can lead to what's called chronic active EBV (CAEBV) disease .
What does mono fatigue feel like? ›Symptoms. You might feel more tired than usual and have a mild fever and sore throat. Your lymph nodes, tissue that normally acts as filters, may swell under your arms and in your neck and groin area. You also may have body aches and pains, swollen tonsils, headache, and even a skin rash.
What could be mistaken for mono? ›Mononucleosis is frequently mistaken for other illnesses, such as strep throat, chronic fatigue, or another infection because the symptoms can overlap, Ramilo says.
Can I never kiss again with mono? ›But the virus is contagious, so it's a good idea to avoid kissing or sharing utensils or cosmetics with anyone who's sick, recently had mono, or may have it now. Note: People can pass mono to others before they know they have it, and even someone who had it a long time ago might spread it, so mono can be hard to avoid.
Can you get mono out of nowhere? ›
Can you just randomly get mono? The viruses that cause mono are common and highly contagious. You may get mono without knowing where you got it from. Some people carry the virus and have no symptoms but can infect others.
Can I give my boyfriend head if I have mono? ›Scientists don't have a detailed understanding of the sexual activities in which mono can be transmitted. But they do know that the virus which causes mono can be found in saliva and genital secretions. It's quite possible that infection could be passed on during oral sex.
Is my boyfriend cheating if I got mono? ›What it comes down to is that it's impossible to say exactly where or from whom you got the infection, but you can reassure your girlfriend that your having mono is not definitive proof of infidelity.
How contagious am I with mono? ›They're most contagious from right before symptoms start until they go away. But they can stay contagious for months after their symptoms have cleared up. Then, the virus stays dormant (inactive) in the body for the rest of their life. That means it can sometimes show up in their spit and get passed on to someone else.
Can you catch mono twice? ›Some studies suggest that it's possible to get mononucleosis again after you recover from mono linked to EBV . More research is needed to understand the extent, if any, that this happens in otherwise healthy adults. But overall, it's highly unlikely to happen.
Is it OK to hug someone with mono? ›You can be around someone with mono, but avoid kissing and touching them. Refrain from sharing utensils and other objects that might be in contact with their bodily fluids.
What are the 4 stages of Epstein-Barr virus? ›For EBV we have a six-stage model of infection (naive Blast, GC, memory, Immediate early lytic, Early lytic and Late lytic) where each stage may or may not be regulated by the immune response.
Is there a quarantine period for mono? ›On average, most people with mono are contagious for around 6 months. In some cases, it could be contagious for up to 18 months. During this time frame, anyone with mono can pass the infection on to others. Mono is more common in teenagers and young adults, particularly students in college.
How long should you quarantine with mono? ›Once your symptoms do appear, they may last for two to four weeks. You can pass the virus to other people through your saliva for up to three months after your symptoms subside. Some studies have reported that you may still be contagious for up to 18 months.
Should you be on bed rest with mono? ›Rest — Mono can cause severe fatigue, although most people recover within two to four weeks. For some, significant tiredness lasts for weeks to months. Early in the infection, it is important to get adequate rest, although complete bed rest is unnecessary.
Is mono A Chlamydia? ›
Despite its nickname, mono is not an STD. . STDs are infections that are transmitted through sexual contact, such as gonorrhea, chlamydia, and HIV.
What are the best foods for mono? ›Eat healthy whole foods to help your immune system fight the mono virus. Eat more antioxidant-rich and anti-inflammatory foods, like: green, leafy vegetables. bell peppers.
What kills Epstein-Barr virus? ›Conventional treatments, including prescription antivirals, are ineffective at treating EBV infections. High-dose intravenous vitamin C is an effective treatment for infection with the Epstein-Barr virus.
Can mono affect your emotions? ›Conclusion: In this largest study to date, infectious mononucleosis in childhood or adolescence was associated with an increased risk of a subsequent depression.
Is mono contagious through air? ›Yes. Among other ways, mono is caught via air. Mononucleosis can spread in other ways other through kissing. Mono's causing virus spreads by airborne droplets.
How do doctors test for mono? ›To conduct a mono test, your health care provider will obtain a blood sample by using either a finger prick or a small needle inserted into a vein in your arm. A small amount of blood is then placed onto a slide, test strip, or other testing device.
What is the first stage of mono? ›Mono may begin slowly with fatigue, a general ill feeling, headache, and sore throat. The sore throat slowly gets worse. Your tonsils become swollen and develop a whitish-yellow covering. Often, the lymph nodes in the neck are swollen and painful.
How long does mono sore throat last? ›Common symptoms include: Severe sore throat, which is almost always present and lasts about 6-10 days. The throat may be very red, with white spots or pus on the tonsils. This can initially look similar to strep throat.
Do I need to wear a mask if I have mono? ›If you have mono, you may want to wear a protective face mask to help prevent spreading the disease to others.
When should you see a doctor for mono? ›Talk to your doctor if: You have mono symptoms for longer than 10 days or you have a severe sore throat for more than a day or two. Your doctor will want to rule out other illnesses, such as strep throat. You have a severe headache that won't go away and a stiff neck, which might be signs of meningitis.
Is mono triggered by stress? ›
Can mono come back with stress? Chronic stress can weaken your immune system, so it's possible that this could be one trigger leading to a bout of recurrent mono.
How long is mono contagious? ›The average length of time a person is contagious after onset of illness is six months. The EB virus remains in the body for life, and periodically can be found in small amounts in the throat in otherwise completely healthy persons. For this reason, it is good to limit the casual sharing of body fluids at all times.
What organ does mono affect? ›Mononucleosis may cause enlargement of the spleen. In extreme cases, your spleen may rupture, causing sharp, sudden pain in the left side of your upper abdomen.
What is like mono but not? ›Some otherwise healthy people with CMV infection develop a mononucleosis-like syndrome. CMV is a type of herpes virus. All herpes viruses remain in your body for the rest of your life after infection. If your immune system becomes weakened in the future, this virus may have the chance to reactivate, causing symptoms.
What is the last stage of mono? ›Convalescent Phase
The final stage of mono is considered the recovery phase. Most symptoms are gone during the convalescent phase, but you may still feel tired or weak. This phase can last up to six months, so it's important to avoid any contact sports, as the spleen may still be enlarged.
Mono patients must increase their fluids, even 2 to 3 times above normal, in the early stages of the illness to help their body fight the virus. Avoid contact sports and vigorous exercise: The spleen, which is a large organ in the left upper abdomen that filters and stores blood, often enlarges in mono.
How did my girlfriend got mono? ›Mononucleosis is an infectious illness that's usually caused by the Epstein-Barr virus (EBV). It's also called mono or “the kissing disease.” You can get the virus through kissing as well as things like sharing drinks or silverware.
Can I be around someone with mono? ›Even though mono is not as contagious as other infections, you need to take certain precautions to prevent it from spreading. You can be around someone with mono, but avoid kissing and touching them. Refrain from sharing utensils and other objects that might be in contact with their bodily fluids.
Can I kiss someone who has had mono before? ›But the virus is contagious, so it's a good idea to avoid kissing or sharing utensils or cosmetics with anyone who's sick, recently had mono, or may have it now. Note: People can pass mono to others before they know they have it, and even someone who had it a long time ago might spread it, so mono can be hard to avoid.
How do you cure mono fast? ›- Stay hydrated. Drink plenty of water, fruit juice, herbal tea, soup, and broth. ...
- Over-the-counter (OTC) medications. Use OTC pain relievers to help bring down a fever and ease headaches and muscle aches. ...
- Throat gargles. ...
- Cool down a fever. ...
- Rest. ...
- Boost your immune system. ...
- Supplements.
Should you stay away from people with mono? ›
There is no vaccine to protect against the Epstein-Barr virus. But you can help protect yourself by avoiding close contact with anyone who has it. If you have mono, don't share the virus with your friends and family as you recover.
Can I go back to work after mono? ›Many people with mono develop an enlarged spleen, which can last for a few weeks or longer. Although you can return to school or work when you are feeling better, it's important to avoid activities that can cause injury to the spleen.
How did I get mono if I haven't kissed anyone? ›While the most common way for the virus to spread is, indeed, through saliva, you don't have to kiss someone with an active strain of it in order to contract it. It can also be transmitted by activities like sharing drinks and using another person's utensils, or through blood and other bodily fluids.
Can you get mono from oral? ›Oral sex: Oral sex between two or more individuals can also promote the spread of Mono.
How do they test for mono? ›To conduct a mono test, your health care provider will obtain a blood sample by using either a finger prick or a small needle inserted into a vein in your arm. A small amount of blood is then placed onto a slide, test strip, or other testing device.
What is the best medicine for mono? ›Antibiotics will not treat viral infections such as mono. Recommendations to help treat the symptoms of mono are as follows: Use over-the-counter pain relievers such as acetaminophen (Tylenol), ibuprofen (Advil or Motrin), or naproxen (Aleve) to help with fever, sore throat, aches and pains.
What activities can you not do with mono? ›Typically, a mono patient should not return to strenuous exercise or contact sports for a minimum of one, and sometimes two, months. Regardless, sports should not be resumed until cleared by the medical provider.